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The phases of sleep and restful sleep

Sleep is the most frequent activity of every human being, being of fundamental importance for the health of our organism. As we learned in the article on "how to take CBD for sleep", sleep disorders are very common and can have negative consequences on many metabolic functions, as well as entailing varying degrees of personal and occupational disability.

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The phases of sleep

Sleep is made up of several cycles of approximately 1:30-2 hours' duration that are repeated 5-6 times each night: for this reason it is advisable to have 7-8 hours of sleep, as a shorter duration would mean a reduction in the number of cycles and/or the possibility of interrupting one of them, which would have a negative influence on the quality of sleep and rest.

Each sleep cycle is composed of 4 phases, of which only the last one represents REM sleep (rapid eye movement)

After 70-90 minutes, sleep begins:

How CBD can help you get better sleep

The rhythm of sleep and wakefulness is regulated by two biological mechanisms:

The endocannabinoid system is primarily responsible for maintaining the psycho-physical balance of our organism, and therefore plays a very important role in the regulation of circadian rhythms and the different phases of sleep (11).

Fluctuations in the concentration of the main endocannabinoids in the brain are related to the sleep-wake cycle, in particular 2-AG is more present during the day and promotes alertness, while Anandamide is more concentrated at night, promoting the appearance of slow brain waves.

The cannabinoid receptor most involved in brain circuits and whose expression influences the regulation of circadian rhythms and the stability of NREM sleep is the CB1 receptor, through which the Endocannabinoid System modulates the different neurotransmitters involved in the different phases of sleep.

One third of the world's population reports having problems related to the quantity or quality of sleep, which can be caused by a variety of factors, from stress or illness to eating habits and daily activities. In addition, sleep disorders can be a trigger for psychiatric problems such as anxiety and depression, as well as having a negative impact on the quality of daily life.

In any of the above-mentioned cases, an altered activity of the Endocannabinoid System can be observed, therefore a treatment with phytocannabinoids could be very promising.

In particular, CBD could represent a very effective tool due to its different properties:

References and Studies on CBD and insomnia

Studies show that among the vast majority of therapeutic users of Cannabis, one of the main reasons for its use is to alleviate sleep problems or improve sleep quality (4-6).

Some studies have shown beneficial effects of CBD on the quantity and quality of sleep (14), increasing its duration and reducing night-time awakenings, as well as being able to alleviate behavioural disorders during REM sleep (3-13).

Other studies have observed an improvement in sleep problems related to phase 3 NREM sleep, due to an inhibitory effect on FAAH enzymes (Anandamide degrading enzymes), which is one of the effects of CBD on the endocannabinoid system (6).

In clinical trials of Sativex, it has been observed that a balanced combination of THC and CBD provides significant improvements in sleep quality (5), and some researchers hypothesise that CBD can improve sleep problems when accompanied by a small proportion of THC, thanks to the synergistic effect between the two compounds. In general, while sporadic use of higher amounts of THC may facilitate a state of relaxation and drowsiness, continued use may negatively influence sleep quality (7-12).

Clinical trials are showing very promising results using CBD products alone or in combination with other cannabinoids such as THC and CBN. (6)

Aceite de CBD: descubre los beneficios

How to take CBD to facilitate restful sleep

To alleviate sleep problems and to improve its restorative effect, it is essential to take CBD internally, especially through sublingual use (not regulated in Spain).

In general, it is advisable to start with a low to medium concentration of cbd oil (5%-10%), initially using minimal doses and gradually increasing the amount of drops until the effect appears. If you want to go down this route, it is advisable to seek advice and follow-up with a specialised health professional.

Other tips to help you get a good night's sleep

The quality of sleep can be influenced both positively and negatively by some daily habits, so there are some good practices that help to facilitate a restful sleep, for example:

Final conclusions on CBD and insomnia

Thanks to its relaxing and modulating effect on the Endocannabinoid System, CBD can represent a valuable therapeutic tool both for dealing with sleep-related problems and for optimising and facilitating its regenerative and restorative effect.

Is CBD safe? Precautions

CBD is a very safe substance even if used in large quantities, but care should be taken when taking medication or if you suffer from heart or blood pressure problems. For this reason in these cases it is always advisable to contact a health professional.
Possible adverse effects
Adverse effects are usually mild to moderate in severity and may include tiredness, drowsiness, dry mouth, dizziness and decreased appetite.

Bibliography:

  1. https://espanol.nichd.nih.gov/salud/temas/sleep/informacion/sucede
  2. https://www.ninds.nih.gov/health-information/patient-caregiver-education/brain-basics-understanding-sleep
  3. https://www.projectcbd.org/medicine/cannabis-sleep-disturbances
  4. Babson, K.A., Bonn-Miller, M.O. (2014) Sleep Disturbances: Implications for Cannabis Use, Cannabis Use Cessation, and Cannabis Use Treatment. Curr Addict Rep 1, 109–114
  5. Russo, E. B., Guy, G. W., & Robson, P. J. (2007). Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine. Chemistry & biodiversity, 4(8), 1729–1743.
  6. Suraev, A. S., Marshall, N. S., Vandrey, R., McCartney, D., Benson, M. J., McGregor, I. S., Grunstein, R. R., & Hoyos, C. M. (2020). Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies. Sleep medicine reviews, 53, 101339.
  7. Kesner, A. J., & Lovinger, D. M. (2020). Cannabinoids, Endocannabinoids and Sleep. Frontiers in molecular neuroscience, 13, 125
  8. Pava, M. J., Makriyannis, A., & Lovinger, D. M. (2016). Endocannabinoid Signaling Regulates Sleep Stability. PloS one, 11(3), e0152473
  9. Méndez-Díaz, M., Ruiz-Contreras, A. E., Cortés-Morelos, J., & Prospéro-García, O. (2021). Cannabinoids and Sleep/Wake Control. Advances in experimental medicine and biology, 1297, 83–95
  10. Hanlon E. C. (2020). Impact of circadian rhythmicity and sleep restriction on circulating endocannabinoid (eCB) N-arachidonoylethanolamine (anandamide). Psychoneuroendocrinology, 111, 104471
  11. Prospéro-García, O., Amancio-Belmont, O., Becerril Meléndez, A. L., Ruiz-Contreras, A. E., & Méndez-Díaz, M. (2016). Endocannabinoids and sleep. Neuroscience and biobehavioral reviews, 71, 671–679.
  12. Babson, K. A., Sottile, J., & Morabito, D. (2017). Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Current psychiatry reports, 19(4), 23
  13. de Almeida, C., Brito, M., Bosaipo, N. B., Pimentel, A. V., Tumas, V., Zuardi, A. W., Crippa, J., Hallak, J., & Eckeli, A. L. (2021). Cannabidiol for Rapid Eye Movement Sleep Behavior Disorder. Movement disorders : official journal of the Movement Disorder Society, 36(7), 1711–1715.
  14. Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente journal, 23, 18–041. https://doi.org/10.7812/TPP/18-041

If you are thinking of starting your own private label CBD project in Spain, either within your company or as a freelancer, you probably aspire to create products from scratch. However, both the sector and the raw material require a series of skills in which very few brands, such as The Beemine Lab, are specialised at the moment.

As experts in manufacturing and distributing CBD products in Spain, in this article we explain everything you need to know to create your own CBD brand.

Keys to Selling CBD in Spain in 2022

We will now take a closer look at the following keys to commercialising CBD in Spain:

The trendy ingredient, Cannabidiol, is a component of the Cannabis plant that, according to the WHO, could have benefits for personal wellbeing and the treatment of certain symptomatologies, but, surely if you are reading this you already know that in Spain and a large part of Europe its commercial use can only be cosmetic, that is to say, for external use. This will be one of the first aspects that you will have to take into account. The legal situation.

In The Beemine Lab we take care of all the legal and administrative documentation to overcome all the barriers and to make the market launch comfortable and agile. We develop the documentation for registration in the European portal for cosmetic products and for exporting these products outside Europe (CNPN).

create your CBD brandOn the other hand, the aforementioned benefits, are you going to specialise in a specific benefit? Are you going to launch a communication plan aimed at a more holistic use of the product? This step is fundamental to choose what information and ingredients you want your product to have.

Another aspect to take into account is the target audience. According to our market research, the majority of the target audience is young women, but depending on the specialisation, you can impact more specific market niches. Some consumers will prefer larger quantity formats, others will prefer design, which is why this step in the development of a CBD white label is also important when choosing the design and format of your product's packaging.

And lastly, the channel: when creating your own brand you need to know which channels you want to position yourself in, whether you are going to go for more traditional channels or opt for e-commerce, or if you want to white label CBD through dropshipping if you are going to need a large quantity of products or start with a small stock.

Sells with CBD Labs in Spain

If you were looking for wholesale CBD suppliers in Spain to market or create your brand from scratch, you are in the right place.

At Laboratorios Beemine we specialise in designing and manufacturing cannabinoid products such as CBD in Spain, with a high concentration of natural, 100% plant-based and animal cruelty-free ingredients. Our laboratory team is at the forefront of current technology and production capabilities:

best cbd products

The best CBD products in Spain

Oils, creams, balms, ... Currently, all kinds of products are marketed by different CBD companies in Spain and Europe. Below we will give you the keys you need to know about the most popular products so that you can create your own brand:

White Label CBD Oils

Currently, CBD oils are the most demanded product on the market, a product with a simple formulation and a wide variety of uses and benefits that make this product a public favourite.

They can be found in various concentrations (3%, 5%, 10%, 20% and 30%) and formats of between 10-30ml. Concentrations of more than 30% require more complex formulations, as at this percentage the oils lose their liquid state and begin to form a viscous mass. This is why the most demanded percentages range between 5% and 20%.

In this dossier you can download all the information you need to create with us your own line of Cannabidiol oils in Spain.

What is the difference between full spectrum, broad spectrum and isolated CBD oil? What is the difference between distilled CBD and isolated CBD? Which is better?

Depending on the extraction method and its purity, the molecule can be obtained completely clean and isolated or with traces of other cannabinoids such as CBD or THC. The difference? Its therapeutic effect and its safety both medically and legally.

Difference between Full Spectrum, Broad Spectrum and Isolated CBD oil

Why do we recommend using CBD isolate in your formulas?

The world's leading consumer brands rely on Mile High Labs CBD isolate as their main ingredient because of its purity and consistency. CBD isolate ensures that you get only crystalline CBD and absolutely no detectable THC.

With over 98% potency, our CBD isolate is extracted in a highly controlled environment and refined to ensure industry-leading purity and consistency.

Our CBD isolate is virtually tasteless and odourless, allowing it to be added to existing products without affecting taste or odour, ensuring your consumer product remains the same.

By choosing CBD isolate, you are getting a stable, fully compatible ingredient that consumers have trusted for years.

industrial hemp

CBD cosmetics to make White Label

CBD cosmetics are booming thanks to their regulating properties for oily skin and soothing properties for sensitive skin. Like the oils, which can be combined as a serum, they have various benefits that adapt to all skin types, offering results for people with a tendency towards acne, dermatitis, etc.

We develop your formula or adapt it to meet your needs. We have a qualified laboratory innovating with the latest technology. We develop samples until we meet your objectives and we advise you during the process.

Our CBD dermocosmetic line is the number 1 in pharmacies in Spain, so if you are thinking of developing your own private label cbd cosmetics, you can count on our CBD private label service to carry out your project.

CBD brand

CBD creams in Spain

Facial creams are the star format of CBD cosmetics, a product that offers a unique experience and results to its users due to the novel benefits of CBD for the skin.

Our formulations have a high percentage of natural ingredients (+95%), giving people with sensitive skin a safe and gentle formulation that they can use for a long time alongside their regular treatments. This is definitely a must-have format if you are thinking of creating your own cosmetic brand with CBD.

Why create your own White Label business with CBD?

Starting from scratch is not easy, and this is compounded by the complexity of the cannabis sector and the lack of familiarity of most laboratories with CBD. Even so, the sector is very attractive because the CBD market is expected to have a turnover of 150 million dollars by 2025, this forecasts an annual growth of more than 12% among users in Spain and all of Europe according to Prohibition Partners, over the next few years more than 3.2 billion customers will be looking for brands like yours. There are already CBD franchises in Spain with more than 60 outlets.

However, the legal risks, the increasing competitiveness of the sector and the need for industry knowledge make it a difficult market in which to establish yourself in the short term.

Advice from established brands such as Laboratorios Beemine may be the key to overcoming both the commercial and production barriers of the CBD market.

Estadísticas del número de personas que consumen cannabis

What is the legality of CBD in Spain?

To the question, is CBD legal in Spain? The answer is simple, but the practice is a bit more complicated.

As mentioned above, the CBD market in Spain is regulated only for cosmetic use. That means that for Cannabidiol in Spain for medicinal or therapeutic use is still limited to users who can access products like Sativex or Epidolex that contain CBD. 1:1 through their specialists.

Importing or producing your brand outside Spain without complying with labelling and marketing requirements can be very expensive. Formats such as flowers or oils are seized by the authorities in many outlets in Spain because they do not meet their requirements.

In addition, the THC content of the products must always be less than 0.02%.

That is why our production process is very strict and we only produce products for external use with CPNP (cosmetic licence).

We develop the documentation for registration in the European cosmetic products portal and for export outside Europe. We carry out the authorisation procedure for food supplements that are new to the market.

We will be pleased to advise you on all aspects of the CPNP. CPNP is the European Cosmetic Product Notification Portal and aims to ensure transparency in the market.

Licence to sell CBD in Spain

In terms of the licences you need to sell CBD in Spain, all you need to do is carry out routine cannabinoid testing of your batches of CBD products to ensure that both the labelling and the content of the product comply with what it promises and with your country's regulatory framework.

Investing in CBD in Spain: Success Stories

There are already established franchises in the sector, such as Herbolarios Navarro, which began by marketing CBD oils from different brands until 2021, when they launched their own brand of CBD oils. 

The success can be seen in the communication emphasis on these same products in the points of sale and the fact that, in just one year, they are available in each and every one of their more than 40 physical shops.

On the other hand, brands such as ours, The Beemine Lab, which is only 4 years old, is already present in more than 400 pharmacies in Spain, which allows us to initiate a very ambitious R&D project in collaboration.

The Beemine Lab is committed to innovation and relies on both private and public institutions, as is the case of its recent collaboration with the Faculty of Pharmacy of the UCM to explore the potential of CBD as a topical active ingredient, ahead of the rest of our international competitors,

This year we will also start with an ambitious internationalisation plan in France and Portugal. In addition, we will continue to expand the team with the young talent that characterises this project, which last year alone doubled its number of employees.

To become a CBD distributor you need to know a series of logistical and legal aspects to take into account, such as: an economic plan, the quality and reliability of CBD products, the marketing possibilities depending on the country, and which distribution platforms you are thinking about using. Here are some of our tips and steps to follow should you want to begin distributing CBD in Spain.

WHAT IS CBD WHOLESALE DISTRIBUTION AND HOW DOES IT WORK?

CBD wholesale distribution consists in acting as an intermediary between a supplier of CBD products and the end customer (retail distribution) or a supplier of CBD products and another CBD distributor (wholesale distribution).

The supplier sets a recommended retail price (hereafter RRP) and a distribution price. The distribution price may be fixed or may vary depending on the agreement and the volume of orders or revenue the distributor generates. Thus, distributors with higher turnover or higher volumes may get a lower distribution price and consequently a higher profit margin.

CBD MARKET PRICES

The distributor’s profit margin is obtained by calculating the difference between the RRP and the distribution price.

One thing to know about the price of CBD products is that it can be high due to the costly extraction process of the raw material and the suppliers' own standards on quality, sustainability or other business practices.

HOW TO BECOME A DISTRIBUTOR FROM SCRATCH?

To start becoming a distributor you will need to have a business plan, commercial vision or a network of potential customers. This business plan will help you to get a glimpse of the market situation, the different prices, agents, suppliers, distributors and offers within the sector.

The market analysis exercise will also help you to determine what market opportunities and niches exist in your country or region, so that you can identify business opportunities in which to develop your business.

WHERE TO FIND BUSINESS OPPORTUNITIES TO SELL CBD PRODUCTS?

Small and medium sized CBD companies start their business in a small area and their special interest in expansion leads them to look for distributors to grow their business with. There are also other ways to identify business opportunities within the Cannabis and CBD sector:

WHAT DO I NEED TO SORT OUT BEFORE I START DISTRIBUTING CBD?

A location to sell the products: Ideally, you should have a location (either digital or physical) to market the products and the relevant sales permits to be able to sell CBD products.

To be aware of the legal situation to market the products: Depending on the legal status of CBD in your region or country, you will have to limit your production either to food or cosmetic permits. Below, we’ll explain the legal situation of CBD in Europe and Spain. 

Initial investment: You will need to have an initial capital investment to place your order to obtain stock and start making profits from the sale of products. 

IS AN INITIAL INVESTMENT NECESSARY? AND DO I NEED TO KEEP A STOCK OF PRODUCTS?

Depending on the supplier, they may provide other distribution models that do not require an initial investment or stock holding. These models usually have a lower profit margin for the distributor.

Supplier's agents: If you already have a number of retail channels or distributors, you can promote the brand, so you’ll be working on commission. That means that you’ll be in charge of being a salesperson for the supplier company.

Supplier's salesperson: You can work for the company selling its catalogue in different sales outlet as one of its employees, for this you will need to have a model or expansion plan to negotiate the terms of the contract with the supplier.

Dropshipping: If you have an ecommerce or digital platform where you can sell the products, you can also sell them through dropshipping. In this type of business you don’t need to keep stock, once the product is sold, the goods are purchased from the supplier and sent directly to the end customer.

Other aspects you should be aware of before starting:

¿Cómo contactar y negociar con proveedores de CBD?

Después del ejercicio de análisis y una vez en mente el plan económico para tu negocio deberás comenzar a contactar con proveedores.  

  1. El distribuidor consigue el contacto del proveedor ya sea a través de su página web, redes sociales, a través de la visita a ferias o convenciones u otras vías de comunicación
  2. El distribuidor se pone en contacto con el proveedor para consultar su catálogo de productos, su PVP y solicitar los precios de distribución. 
  3. Consultará también los datos pertinentes (análisis, certificados de materia prima, etc.) y si lo desea podrá solicitar una muestra del producto antes de realizar su pedido.
  4. Una vez el distribuidor haya llegado a una decisión retomará la comunicación con el proveedor indicando el volumen de productos que precisa para su negocio y las fechas de pago del pedido. 
  5. El proveedor realiza el envío del producto al distribuidor. El distribuidor recibe el pedido y puede comenzar a comercializar los productos con el PVP y las condiciones acordadas con el proveedor. 

Aspectos básicos que debes conocer antes de vender CBD 

Cuál elegir depende principalmente de los aspectos legales y comerciales de los productos de Cannabis en tu país o región. Por ejemplo si en tu país está penalizado la comercialización del THC, lo mejor será elegir un aceite de CBD Broad spectrum o Isolate para evitar posibles problemas legales.

Si quieres obtener información más completa sobre CBD consulta nuestro artículo: ¿Qué es el CBD? Historia, beneficios y propiedades.

Cómo identificar proveedores de calidad

Antes de comprar aceite de CBD u otros derivados del cáñamo industrial debes cerciorarte de que, tanto el producto, la materia prima y el proveedor, es de calidad.

Los proveedores oficiales cuentan con análisis a terceros (realizados por laboratorios externos) de los productos para analizar la cantidad de Cannabidiol u otros cannabinoides que contiene el producto. Este análisis debería estar disponible en la web de los proveedores junto a otros sellos de calidad como sellos GMP, ISO o cualquier otro código o sistematización que confirme la calidad de los productos a través de agentes externos a la empresa. 

Aspectos legales a tener en cuenta para vender CBD

La situación legal del cáñamo industrial y más concretamente del CBD depende de la legislación de cada país. Por ejemplo, en España es legal el cultivo y cosecha de de cáñamo industrial, siempre y cuando las cepas contengan un porcentaje menor a 0,2% de THC.

Sin embargo, la extracción de CBD aún no es legal en España, por lo que las materias primas se obtienen. 

Situación legal del CBD en Europa

La OMS recomendó en enero de 2019 la retirada del Cannabis de la lista IV de sustancias prohibidas de la Convención sobre drogas de 1961 (3). Desafortunadamente hasta el momento se mantienen las restricciones sobre la planta del Cannabis.

Esta acción impulsará la regulación del Cannabis para uso medicinal y el uso ingerido en España, pero de momento deberemos esperar. 

Situación legal del CBD en España

El CBD es legal, pero no puede venderse para consumo humano. A falta de estudios clínicos que impulsen la regularización del Cannabis Medicinal, concretamente del CBD, la EFSA (Autoridad Europea de Seguridad Alimentaria) no permite su comercialización como alimento o complemento alimenticio al considerarse nuevo alimento. 

Por el momento en España y gran parte de Europa la comercialización de productos con CBD se ciñe al uso externo y por lo tanto los productos solo pueden ser recomendados para este modo de empleo y comercializados como cosméticos. (4)

Por otra parte, el consumo y posesión es ilegal solo en la vía y lugares públicos. Se permite el cultivo, la posesión y el consumo privados en diversos grados según la Comunidad Autónoma o Región. 

Hazte distribuidor de CBD con The Beemine Lab

¿Quieres hacerte distribuidor de los productos con CBD de The Beemine Lab? Echa un vistazo a nuestra página de distribución o consulta nuestro catálogo completo.

Teléfono y Whatsapp:

E-mail: sales@beemine.farm

Bibliografía:

  1. Annex 1- Extract from the Report of the 41st Expert Committee on Drug Dependence: Cannabis and cannabis-related substances. (2019)
  2. CANNABIDIOL (CBD) Pre-Review Report. Expert Committee on Drug Dependence. Thirty-ninth Meeting. Geneva, 6-10 November. (2017)
  3. Towards a responsible, innovative and high-quality cannabidiol industry. Centre for Medical Cannabis. (2019)
  4.  Situación legal del CBD en España. THC Abogados. (2019)

Among the diseases that can affect the musculoskeletal system, causing pain and inflammation, problems affecting the knees, one of the most complex joints in the human body due to its crucial role in maintaining posture and movement, stand out. Knee pain can have different causes and manifest itself in acute or chronic form, causing varying degrees of personal and occupational incapacity and negatively influencing the quality of life of the sufferer.

One of the most frequent causes of knee pain is osteoarthritis (OA), which occurs in 4% of the population and represents the eleventh leading cause of disability worldwide.

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Most common causes of knee pain

The knee is a joint composed of:

There are different problems that can affect the knees, causing pain and inflammation, and they can occur at any age, and may be related to specific mechanical trauma, the presence of a disease or wear and tear due to the passage of time. Being overweight can play a crucial role in the development of knee pain and problems, as can many physical and heavy sports or jobs.

The most common causes of knee pain can be:

Diagnóstico y tratamientos para el dolor de rodilla

Diagnosis is made by physical examination and using techniques such as arthroscopy and magnetic resonance imaging.

Depending on the severity of the problem, analgesic and anti-inflammatory drugs are usually prescribed as well as compensatory physical exercise and weight control strategies, as postural changes due to knee problems can also lead to back pain.

In the most severe cases, surgery is necessary to heal bone fractures, tendon, ligament and meniscus injuries.

(1-2)

How CBD works against knee pain

The endocannabinoid system, which is dedicated to maintaining the psycho-physical balance of our organism, is present in both the muscular and skeletal systems, participating in the processes of recovery from an injury or fracture and also modulating inflammatory processes and pain sensation thanks to its close relationship with the nervous and immune systems (3).

Different studies have observed the presence of endocannabinoid receptors CB1 and CB2 in the synovial fluid, and in people suffering from osteoarthritis or rheumatoid arthritis, the presence of the main endocannabinoids such as anandamide and 2-AG, as well as the FAAH degrading enzyme, has also been recorded. (4) (5) (6)

CBD, thanks to its modulatory activity on the endocannabinoid system, can alleviate knee pain resulting from various causes. In particular, CBD would provide

Studies on the effect of CBD in animals

Numerous studies have recorded an analgesic, anti-inflammatory and neuroprotective effect of CBD in experimental models of osteoarthritis in animals, also observing a preventive effect against possible neurological damage and consequent neuropathic pain, and confirming the capacity to slow down the degenerative process, with doses of 5 mg/kg or 25 mg/day.

(7-8-9-10).

While most of the studies cited above have used the endovenous or transdermal route, there is one study carried out on dogs with OA using the ingested route: the results have shown significant improvements in symptoms after taking 4 mg of CBD a day for a month.

(11)

Studies on the effect of CBD in humans

Preclinical evidence shows the beneficial effects of CBD in relieving pain and reducing inflammation in joints, demonstrating how phytocannabinoid treatments can represent a safe, effective and economical option for treating acute or chronic problems such as arthritis and osteoarthritis of the knee.

(12-13)

More specifically, significant improvements have been reported following transdermal application of synthetic CBD and a clinical trial is currently under preparation to study the effectiveness of oral applications of CBD in patients with osteoarthritis of the knee.

(14-15)

El aceite de cbd ayuda contra todo tipo de dolores musculares. Descubre sus beneficios y propiedades.

How to take CBD for knee pain

According to studies, it is possible to take CBD internally in inhaled, sublingual and ingested form, as well as externally in topical and transdermal form, to treat knee pain.

The inhaled form, which ensures maximum and immediate effect, is used to cope with acute pain, using what is needed at the time.

The sublingual form (not regulated in Spain) is used to obtain a continuous and stable effect and represents a better option compared to the ingested form (not regulated in Spain). In general, it is advisable to start with a low to medium concentration CBD oil (5%-10%), starting with minimal doses and gradually increasing every two days until the effects appear. In this case, it is highly recommended to seek advice and monitoring by a specialised health professional.

Through the topical route, the effect is concentrated in the area of application, so it is also highly recommended to use CBD-rich oils, creams and ointments that can be applied 3-4 times a day, gently massaging the entire knee area until they are completely absorbed.

There are also transdermal patches on the market (including knee pads) which, in addition to having a direct effect on the area of application, allow a systemic effect to be obtained.

Precautions: Is CBD safe?

CBD is a very safe substance even if used in large quantities, but care should be taken when taking medication or if you have heart or blood pressure problems. For this reason in these cases it is always advisable to contact a health professional.

Possible adverse effects

Adverse effects are usually mild to moderate in severity and may include tiredness, drowsiness, dry mouth, dizziness and decreased appetite.

Bibliography:

  1. https://medlineplus.gov/spanish/kneeinjuriesanddisorders.html
  2. https://medlineplus.gov/spanish/ency/article/003187.htm
  3. Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018). The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 43(1), 52–79.
  4. Rzeczycki, P., Rasner, C., Lammlin, L., Junginger, L., Goldman, S., Bergman, R., Redding, S., Knights, A. J., Elliott, M., & Maerz, T. (2021). Cannabinoid receptor type 2 is upregulated in synovium following joint injury and mediates anti-inflammatory effects in synovial fibroblasts and macrophages. Osteoarthritis and cartilage, 29(12), 1720–1731.
  5. Richardson, D., Pearson, R. G., Kurian, N., Latif, M. L., Garle, M. J., Barrett, D. A., Kendall, D. A., Scammell, B. E., Reeve, A. J., & Chapman, V. (2008). Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. Arthritis research & therapy, 10(2), R43.
  6. Valastro, C., Campanile, D., Marinaro, M., Franchini, D., Piscitelli, F., Verde, R., Di Marzo, V., & Di Bello, A. (2017). Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study. BMC veterinary research, 13(1), 309. https://doi.org/10.1186/s12917-017-1245-7
  7. Kogan NM, Melamed E, Wasserman E, et al. Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. 2015 Oct;30(10)
  8. Malfait, A. M., Gallily, R., Sumariwalla, P. F., Malik, A. S., Andreakos, E., Mechoulam, R., & Feldmann, M. (2000). The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proceedings of the National Academy of Sciences of the United States of America, 97(17), 9561–9566.
  9. Philpott, H. T., O'Brien, M., & McDougall, J. J. (2017). Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain, 158(12), 2442–2451.
  10. Hammell, D. C., Zhang, L. P., Ma, F., Abshire, S. M., McIlwrath, S. L., Stinchcomb, A. L., & Westlund, K. N. (2016). Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. European journal of pain (London, England), 20(6), 936–948.
  11. Gamble, L. J., Boesch, J. M., Frye, C. W., Schwark, W. S., Mann, S., Wolfe, L., Brown, H., Berthelsen, E. S., & Wakshlag, J. J. (2018). Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs. Frontiers in veterinary science, 5, 165
  12. Miller, R. J., & Miller, R. E. (2017). Is cannabis an effective treatment for joint pain?. Clinical and experimental rheumatology, 35 Suppl 107(5), 59–67.
  13. Vannabouathong, C., Zhu, M., Chang, Y., & Bhandari, M. (2021). Can Medical Cannabis Therapies be Cost-Effective in the Non-Surgical Management of Chronic Knee Pain?. Clinical medicine insights. Arthritis and musculoskeletal disorders, 14, 11795441211002492.
  14. Hunter, D.J., Oldfield, G., Tich, N., Messenheimer, J.A., & Sebree, T.B. (2018). Synthetic transdermal cannabidiol for the treatment of knee pain due to osteoarthritis. Osteoarthritis and Cartilage, 26.
  15. https://www.clinicaltrials.gov/ct2/show/study/NCT05020028

What is depression?

Depression is a mood disorder, i.e. it affects the emotional and psychological state and is reflected in social and professional functioning, being the leading cause of disability worldwide.

Depression is an illness that affects 5% of the adult population but can occur at all ages, interfering negatively with a person's quality of life, in the personal, family, work and social spheres. In its most severe form it can even lead to suicide.

1-2-3

Symptoms of depression

Types of depression

The most common types are mainly characterised by duration:

There are other forms related to other factors:

Causes and Treatment of depression

Genetic, biological, psychological, environmental and socio-cultural factors may be involved. In many cases depression is triggered by a traumatic event that has emotional impact and/or physical consequences.

At the brain level, depression is related to low levels of dopamine, serotonin and noradrenaline, the neurotransmitters that pharmacological treatment stimulates through antidepressants. Although drugs can help at the symptomatological level, treatment involves different psychological therapy strategies.

Depression and the Endocannabinoid System

El Sistema Endocannabinoide es el sistema fisiológico que se encarga de mantener el equilibrio de nuestro organismo y juega un papel crucial en la regulación de los mecanismos de estrés, tanto a nivel físico como psicológico. Puedes informarte más en este artículo sobre cómo el CBD ayuda a reducir altos niveles de estrés.

A nivel fisiológico, el SEC interactúa con diferentes neurotransmisores, incluyendo la serotonina, la dopamina y la noradrenalina. Esta acción es debida principalmente a los receptores CB1, presentes sobre todo en el Sistema Nervioso Central y a los 5HT1a, receptores de la serotonina. (5)

Se ha hipotetizado, como ocurre en otras enfermedades, que un desequilibrio del Sistema Endocannabinoide puede dar origen a los mecanismos fisiopatológicos de la depresión.

Por esta razón, gracias a un tratamiento con fitocannabinoides es posible modular los niveles de los neurotransmisores mencionados, mejorando los síntomas físicos y psicológicos de la depresión. (6)

Aunque el uso del THC podría resultar positivo en algunos casos en los cuales el consumo es controlado y supervisado por un profesional, en la mayoría de los casos la psicoactividad podría llevar a un empeoramiento de los síntomas, siendo el abuso de THC un factor de comorbilidad de la depresión. (7)(8)(9)

En cambio, el uso del CBD podría representar una buena herramienta terapéutica por sus diferentes mecanismos de acción, sus efectos y por no ser psicoactivo.

el CBD regula el sueño, apetito y el estado de ánimo

How CBD could help treat depression?

Las propiedades del CBD pueden ser beneficiosas para aliviar diferentes síntomas de la depresión:

(10-11-12-13)

El aceite de cbd ayuda contra todo tipo de dolores musculares. Descubre sus beneficios y propiedades.

What do studies say about the use of CBD for depressive symptoms?

There are studies in both animals and humans that demonstrate the safety and efficacy of CBD in the treatment of depressive symptoms, justifying the need for more comprehensive and controlled studies.

In addition, there is strong clinical evidence for the efficacy of CBD in alleviating symptoms of anxiety, which is often associated with depressive disorders. Several clinical trials are studying its anxiolytic properties in depth.

(10-11-12-13-14)

How to use CBD for depression?

In order to take advantage of the properties of CBD that help alleviate depressive symptoms, it is necessary to use it internally (not regulated in Spain), both through inhalation and sublingual use. It is advisable to start with low to medium concentration products (5%-10%), initially using minimal doses (1-2 drops) and gradually increasing the dose until the effects appear. In any case, when opting for this route, it is always advisable to contact a specialised professional who can offer personalised advice, follow-up and, if possible, psychological therapeutic support.Precautions: Is CBD safe?

CBD is a very safe substance even if used in large quantities, but care should be taken when taking medication or if you suffer from heart or blood pressure problems. For this reason in these cases it is always advisable to contact a health professional.

Possible side effects

Side effects are usually mild to moderate and may include tiredness, drowsiness, dry mouth, dizziness and decreased appetite.

Bibliography:

terature:https://medlineplus.gov/spanish/ency/article/003213.htm

  1. https://www.nimh.nih.gov/health/publications/espanol/depresion-sp
  2. https://www.who.int/es/news-room/fact-sheets/detail/depression
  3. https://www.elsevier.es/es-revista-farmacia-profesional-3-articulo-antidepresivos-13081504
  4. https://www.fundacion-canna.es/sistema-endocannabinoide
  5. Rana, T., Behl, T., Sehgal, A., Mehta, V., Singh, S., Kumar, R., & Bungau, S. (2021). Integrating Endocannabinoid Signalling In Depression. Journal of molecular neuroscience : MN, 71(10), 2022–2034.
  6. Onaemo, V. N., Fawehinmi, T. O., & D'Arcy, C. (2021). Comorbid Cannabis Use Disorder with Major Depression and Generalized Anxiety Disorder: A Systematic Review with Meta-analysis of Nationally Representative Epidemiological Surveys. Journal of affective disorders, 281, 467–475.
  7. Lowe, D., Sasiadek, J. D., Coles, A. S., & George, T. P. (2019). Cannabis and mental illness: a review. European archives of psychiatry and clinical neuroscience, 269(1), 107–120.
  8. Feingold, D., & Weinstein, A. (2021). Cannabis and Depression. Advances in experimental medicine and biology, 1264, 67–80.
  9. García-Gutiérrez, M. S., Navarrete, F., Gasparyan, A., Austrich-Olivares, A., Sala, F., & Manzanares, J. (2020). Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders. Biomolecules, 10(11), 1575.
  10. Oberbarnscheidt, T., & Miller, N. S. (2020). The Impact of Cannabidiol on Psychiatric and Medical Conditions. Journal of clinical medicine research, 12(7), 393–403.
  11. Crippa, J. A., Guimarães, F. S., Campos, A. C., & Zuardi, A. W. (2018). Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. Frontiers in immunology, 9, 2009. 
  12. De Mello Schier, A. R., de Oliveira Ribeiro, N. P., Coutinho, D. S., Machado, S., Arias-Carrión, O., Crippa, J. A., Zuardi, A. W., Nardi, A. E., & Silva, A. C. (2014). Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS & neurological disorders drug targets, 13(6), 953–960. 
  13. Silote, G. P., Sartim, A., Sales, A., Eskelund, A., Guimarães, F. S., Wegener, G., & Joca, S. (2019). Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms. Journal of chemical neuroanatomy, 98,

CBD oil has a wide range of health benefits. From relieving chronic pain to achieving a state of relaxation in diseases such as epilepsy or anxiety. But we can't forget that cbd is also anti-inflammatory.

Many people wonder whether cbd has better anti-inflammatory properties than ibuprofen. So, to clear up any doubts, we are going to talk about the anti-inflammatory power of CBD.

CBD vs ibuprofen

In this section we will assess the effects of CBD vs ibuprofen, the most commonly used drug to combat inflammatory effects and bodily discomfort.

Many people turn to ibuprofen when they have some kind of discomfort or inflammation in their body. Its effectiveness is more than proven, although like any medical drug, it should not be abused without a doctor's prescription.

CBD has become an alternative for those who suffer from inflammation and chronic pain and do not want to take chemical medications.

But can CBD really be a substitute for ibuprofen?

Ibuprofen has a more immediate effect (or at least is felt in a shorter period of time), but CBD remedies require longer exposure in the body to have their effects. However, this will depend on the dose used.

It is also worth bearing in mind that medications can become habit-forming and lose their effectiveness after prolonged use, as is the case with ibuprofen. However, this is not the case with CBD, and increasing the dosage does not pose as much of a health risk as using ibuprofen.

Ultimately, CBD oil and its derivatives can help in the treatment of pain and inflammation over a longer period of time, whereas ibuprofen will provide relief at specific times and more quickly. However, if CBD is to be used as an anti-inflammatory, it is best to seek the advice of a medical professional.

Efectos del CBD antiinflamatorio

CBD anti-inflammatory properties

There are certain ailments or illnesses that, after scientific study, it has been shown that their consequences and effects on the body can be minimised by using cannabidiol as an anti-inflammatory. Some cases in which cbd is anti-inflammatory:

In short, CBD can contribute with its inflammatory effect to:

CBD oil for inflammation

And you are probably wondering what happens if the inflammation is internal. Well, CBD can also be taken in the form of consumable oil, capsules, infusions, jelly beans, etc. However, it must always be supervised by a medical professional.

CBD oil can help relieve pain and inflammation and with fewer side effects than taking ibuprofen, both in the short and long term.

CBD oils are among the most common compounds used by people today. This is because it allows for better and more effective dosing, as well as a long shelf life. The texture of CBD is very similar to other oils, although alcohol is used as a carrier instead of oil. This gives it a longer shelf life and makes it easier for herbalists and naturopaths to mix it with other herbs or essential oils that have anti-inflammatory properties among their components. However, this alcohol-infused oil cannot be ingested.

To take CBD for inflammation, simply measure the recommended or desired dose with the dropper containing the product and place it under the tongue for a quick effect, or ingest it for a slower, more controlled effect.

In general, it is estimated that oils and sprays taken orally are absorbed into the bloodstream in an average of 10-45 minutes.

Aceites de cannabis para el dolor y reducir la inflamación

CBD anti-inflammatory cream

When using CBD as an anti-inflammatory, it is important to consider where the inflammation is located. Swelling and irritation on external areas caused by rashes or injuries can be treated with CBD ointments, lotions or creams applied directly to the affected area.

Any inflammation of the skin also benefits from ingesting CBD oil. However, the most common mode of treatment is topical (on the skin). This allows the cannabidiol to concentrate in the affected local tissues.

We can use the anti-inflammatory cannabidiol topically in cases of:

In general, CBD balms and creams can take longer to reach the pores of the skin, up to 90 minutes if rubbed into the affected area. Because CBD takes longer to take effect and is slower to work, balms and topicals often have higher concentrations of CBD added to them to make them work. Similarly, metabolism and body fat influence the way CBD is absorbed by the body.

What are the best anti-inflammatory creams with CBD?

CBD creams and ointments are dermatological and cosmetic products that contain cannabidiol in their composition, either using oil or extract.

Below, we are going to talk about two topical solutions containing CBD. One is the CBD recovery balm and the other is Alivium CBD cold effect.

CBD Recovery Balm

A remedy in case of muscle and joint injuries is to use the muscle recovery balm with cbd, as it will activate and improve the body's well-being.

In addition, this product contains 95.95% natural ingredients that have been certified by the European Union and are animal cruelty-free. In addition, it has been produced in Spain and is dermatologically tested.

This cannabidiol balm is composed of natural ingredients that act on the affected area immediately and provides benefits such as:

Rich in Cannabidiol.
It tones and moisturises the skin, giving a feeling of recovery.
It is ideal to apply before, during or after sport or daily tasks.
It has an immediate cold effect.
It gives a great feeling of body relaxation.

Its ingredients include CBD, essential oils (hemp, mint, lemongrass, clove, eucalyptus, arnica and rosehip) and honey.

To use, a small amount of the balm should be applied to the affected area or area to be treated, spreading the product with a gentle massage in circular movements to ensure complete absorption. It can be used at any time of the day.

Similarly, the CBD recovery balm can be used in combination with other products to achieve a greater effect and can be used on hands and legs after physical exercise.

Alivium CBD Cold Effect

Alivium CBD cream has a revolutionary formula composed of honey and cannabidiol (CBD). CBD acts on the endocannabinoid system, which regulates essential functions in the body, and reduces the sensation of pain.

This product is composed of 95.9% natural ingredients which are CBD, honey, mental, lemongrass, clove, arnica, rosehip and eucalyptus. All these elements contribute to Alivium giving us a series of benefits such as:

To use, apply a small amount to the area to be treated and spread with a gentle massage in circular motions for complete absorption. It can be used 2 or 3 times a day to comfort the skin and use cbd as an anti-inflammatory.

Bibliography:

  1. Fatouros, I., & Jamurtas, A. (2016). Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance. Journal of Inflammation Research, 9, 175 – 186.
  2. McCartney, D., Benson, M.J., Desbrow, B. et al. Cannabidiol and Sports Performance: a Narrative Review of Relevant Evidence and Recommendations for Future Research. Sports Med – Open 6, 27 (2020). https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-020-00251-0
  3. Langer, H. T., Mossakowski, A. A., Pathak, S., Mascal, M. J., & Baar, K. (2021). Cannabidiol does not impair anabolic signaling following eccentric contractions in rats. International journal of sport nutrition and exercise metabolism31(2), 93-100. https://journals.humankinetics.com/view/journals/ijsnem/31/2/article-p93.xml
  4. Kogan NM, Melamed E, Wasserman E, et al. Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. 2015 Oct;30(10):1905-1913. DOI: 10.1002/jbmr.2513.
  5. Cruz, Candelaria. (2020). The effects of Cannabidiol (CBD) on Perceived Muscle Soreness, Inflammation, and Performance after Bouts of Eccentric Exercise of the Elbow Flexors.
  6. Cochrane-Snyman KC, Cruz C, Morales J, Coles M. The Effects of Cannabidiol Oil on Noninvasive Measures of Muscle Damage in Men. Medicine and Science in Sports and Exercise. 2021 Jul;53(7):1460-1472. DOI: 10.1249/mss.0000000000002606.
  7. Kasper, A.M., Sparks, S.A., Hooks, M.C., Skeer, M., Webb, B., Nia, H., Morton, J., & Close, G. (2020). High Prevalence of Cannabidiol Use Within Male Professional Rugby Union and League Players: A Quest for Pain Relief and Enhanced Recovery. International journal of sport nutrition and exercise metabolism, 1-8.
  8. Pellati, Federica & Borgonetti, Vittoria & Brighenti, Virginia & Biagi, Marco & Benvenuti, Stefania & Corsi, Lorenzo. (2018). Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer. BioMed Research International. 2018. 1-15. 10.1155/2018/1691428.
  9. Burstein S. Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic & Medicinal Chemistry. 2015 Apr;23(7):1377-1385. DOI: 10.1016/j.bmc.2015.01.059.
  10. Hobbs, Jack & Vazquez, Allegra & Remijan, Nicholas & Trotter, Roxanne & McMillan, Thomas & Freedman, Kimberly & Wei, Yuren & Woelfel, Keith & Arnold, Olivia & Wolfe, Lisa & Johnson, Sarah & Weir, Tiffany. (2020). Evaluation of pharmacokinetics and acute anti?inflammatory potential of two oral cannabidiol preparations in healthy adults. Phytotherapy Research. 34. 10.1002/ptr.6651.
  11. Sangiovanni, E., Fumagalli, M., Pacchetti, B., Piazza, S., Magnavacca, A., Khalilpour, S., Melzi, G., Martinelli, G., & Dell’Agli, M. (2019). Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury. Phytotherapy research : PTR, 33(8), 2083–2093. https://doi.org/10.1002/ptr.6400
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